My knowledge of the subject is sketchy, but my understanding is that, unless you have a MASSIVE machine -- and probably nothing you could fit in your basement would qualify -- the machine won't have the rigidity, or the horsepower, required to be able to handle a negative rake cutter effectively.
For home shop use, IMO the most practical toolbits for a home shop are HSS, ground to appropriate positive rake angles for the material being machined.
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