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  • Evan, glad you're doing better. I'm interested in the thought process that got you to sildenafil. Can you describe how you arrived at that chemical?
    Last edited by 914Wilhelm; 06-29-2013, 10:23 PM. Reason: I kain't spel

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    • Evan,I haven't been here much lately,but you have been a friend,and I certainly wish you well and healthy.

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      • Do make sure to give your doctor some credit evan. He must be really damn smart if hes letting you do his job for him!

        Very intresting about the dosage however. And its effects.
        Play Brutal Nature, Black Moons free to play highly realistic voxel sandbox game.

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        • Originally posted by Wilhelm
          I'm interested in the thought process that got you to sildenafil. Can you describe how you arrived at that chemical?
          That is difficult to explain. I do a lot of research, especially when I really need to like this week. I have always had this ability to somehow tune in to seemingly unrelated subjects because something about it caused a little light to turn on inside my head. Don't ask me how it works, I don't know. But, many times it takes me directly to something that turns out to be very strongly related to what I was studying.

          In this case it was this study:

          Abstract

          Phosphodiesterase-5 inhibitors (PDE5Is) improve erectile function by enhancing nitric oxide availability in the penis and its supplying vasculature, resulting in vasodilation and increased blood flow. PDE5Is might benefit cardiovascular diseases because phosphodiesterase-5 is also located elsewhere in the body, including the pulmonary and systemic vasculature and in hypertrophied myocardium. PDE5Is are approved for pulmonary arterial hypertension, given that they improved several hemodynamic and clinical parameters in large randomized trials. Initial evidence suggests that PDE5Is benefit patients with congestive heart failure and secondary pulmonary hypertension. PDE5Is seem to improve hemodynamic and clinical parameters in patients with high-altitude pulmonary edema (HAPE) and high-altitude pulmonary hypertension. In climbers with prior episodes of HAPE, PDE5Is prevented HAPE in 2 small randomized trials. In small randomized trials of PDE5Is, patients with Raynaud's phenomenon demonstrated improved blood flow, fewer symptoms and frequency of attacks, and resolution of digital ulcers. In addition to enhancing vasodilation, PDE5Is seem to protect the myocardium through complex pathways that involve nitric oxide, cyclic guanosine monophosphate, protein kinase G, extracellular-signal-regulated kinase, B-cell lymphoma protein-2, and Rho kinase inhibition. In animal models of acute myocardial infarction, PDE5Is consistently reduced infarct size indicating cardioprotection and PDE5Is also promote reverse remodeling and reduce myocardial apoptosis, fibrosis, and hypertrophy. PDE5Is might also benefit patients with treatment-resistant hypertension, preeclampsia, or peripheral arterial disease. This review presents the pathophysiology and trial data with regard to the use of PDE5Is for cardiac diseases.
          Medscape is one of the very best places to look up medical information but you need to know the big words.

          http://www.medscape.com/viewarticle/755975

          It was the highlighted line that got me going on the subject. I spend a lot of time reading studies related to high altitude climbers breathing issues because my issues act the same as somebody at high altitude. When I read that line it immediately made me think there may well be a connection. There is.
          Free software for calculating bolt circles and similar: Click Here

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          • Originally posted by Evan View Post

            It was the highlighted line that got me going on the subject. I spend a lot of time reading studies related to high altitude climbers breathing issues because my issues act the same as somebody at high altitude. When I read that line it immediately made me think there may well be a connection. There is.

            I was just reading a similar study after my sister (who is a nurse and outdoor adventurer) mentioned mountain climbers popping viagra before a steep ascent. All jokes aside, it was an interesting article.

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            • Originally posted by Fasttrack View Post
              I was just reading a similar study after my sister (who is a nurse and outdoor adventurer) mentioned mountain climbers popping viagra before a steep ascent. All jokes aside, it was an interesting article.
              Ohhh just one more joke.
              Nah, thats not for breathing, Thats so they have another emergency rock ancor handy!
              Play Brutal Nature, Black Moons free to play highly realistic voxel sandbox game.

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              • It's odd really I've been taking Viagra for blood pressure for a few years, on my docs advice, works
                Mark

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                • Glad your getting a handle on it Evan .. good for you.

                  I can attest to the blood pressure effects of the big V .. Every year I have/had a work
                  physical for work .. if anything at all was out of the norm .. sight,hearing,blood pres,ekg etc
                  we were bad ordered, Engr's license taken. My blood pres runs a little high and it was
                  a little cheater of mine .. to take a 1/2 Viagra before going in. It never let me down.

                  Doesn't surprise anybody here .. that you figured things out .. your a pretty sharp knife in
                  the drawer ... grin
                  John Titor, when are you.

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                  • Originally posted by Evan View Post
                    Thanks. Looks like I may just make it, again.
                    That was your 40,000th post. It could not have been better.
                    Allan Ostling

                    Phoenix, Arizona

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                    • Congrats on hiting 40,000 posts evan! I hope you keep us good company for another 40,000 posts!
                      Play Brutal Nature, Black Moons free to play highly realistic voxel sandbox game.

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                      • Wasn't viagra an accidental spinoff from research into blood pressure medication?

                        Glad it's helping you.

                        Tim

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                        • I seem to remember a news article a few weeks ago (BBC, I think) announcing that they were going to start treating British people with it on the NHS, for blood pressure and heart problems and something about dementia problems.

                          coincided exactly with the time that Pfizer patent ran out in the uk .

                          which makes me think they had known about ..but were too mean to allow it because of the price before.
                          all the best.markj

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                          • It has been known about for some time but only for a very specific application. It is sold under a different name, Revatio, although it is exactly the same drug. Because it can be prescribed to children as young as one year old it wouldn't quite fly too well if it were still called Viagra. The medical problem it is FDA approved for is PAH, Pulmonary Atrial Hypertension. This is a very rare and deadly disease both in adults and children. It is very similar to the problem I have but for a different part of the body. Current trials are now focusing on the problem I have. While my cause is exceedingly rare there are other more common causes for essentially the same symptoms.

                            It seems to be working very well. My sitting blood pressure is staying at 120 or even lower instead of as high as 140 while sitting and even higher when lying nearly flat. Even lying down it still keeps it at no more than 120 or so instead of 150 to 160. My standing pressure doesn't go down even more and in fact is lifted a bit higher from 80 to 90 or even 100 to 110. It is evening out my blood pressure both lower when it should and higher when it should. This is a new drug for this application. No previous drug has worked in this way.
                            Last edited by Evan; 06-29-2013, 06:19 PM.
                            Free software for calculating bolt circles and similar: Click Here

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                            • Here is an example in healthy people.



                              For people with large changes between sitting and standing it works even better, still maintaining a close to normal range.
                              Free software for calculating bolt circles and similar: Click Here

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                              • If you are going to use Viagra or sildanafil then DO NOT TAKE YOUR GTN SPRAY AT THE SAME TIME.
                                You won't need to worry about high blood pressure, you won't have any, I tried it accidentally and passed out on a chair in the kitchen, it was not pretty I can assure you, I did think I was about to die, I came round after about 15 mins managed to take my BP with a wrist monitor after about 3 goes with E3 error on the thing and it was just measurable, several ultra strong coffees later it was back up to just below normal, I had taken aspirin, bisoperol, plavix, ramprl, sildanafil, and GTN within several hours,
                                Just a warning in case
                                Regards
                                Mark

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